CURRICULUM VITAE OF

J.C. Callaway, Ph.D.

28 May 1999

PERSONAL DATA

Date and place of birth: May 13, 1958 Galveston, Texas
Status: USA citizen, Finnish resident since 1988

Present address: Department of Pharmaceutical Chemistry
University of Kuopio POB 1627
FIN-70211 Kuopio, Finland
Tel: 358 17 163 601
Fax: 358 17 162 456
e-mail: callaway@uku.fi

Professional description: My primary research areas are in the medical sciences. I have been trained as an analytical and synthetic organic chemist, with a strong background in pharmacognosy and extensive experience in the quantitative analysis of drugs in plants and biological fluids.

RECENT APPOINTMENTS

Docent of Ethnopharmacology, Department of Pharmacology and Toxicology, University of Kuopio, Finland
Scientific Advisory Board Member of the Heffter Institute
Advisory Board Member of the Hemp Food Association (www.hempfood.com)
Editorial Advisory Board Member of Integration: Journal for Mind-Moving Plants and Culture
Editorial Advisory Board Member of Eleusis, Bollettino della Società Italiana per lo Studio degli di Coscienza
Editorial Advisory Board Member of the Journal of Cannabis Therapeutics (first issue due in early 2000)

Active Memberships

International Hemp Association (IHA)
Hemp Industries Association (HIA)

EDUCATION

8/76- 5/80 Henderson Univ.; Arkansas, USA B.Sc. in chemistry (music scholarship)
8/80-5/84 Univ. of Mississippi; Mississippi, USA M.Sc. in organic chemistry
8/90-12/94 Univ. of Kuopio, Finland Ph.D. in medicinal chemistry
12/98 Univ. of Kuopio, Finland Docent of Ethnopharmacology

JOB EXPERIENCE IN THE MEDICAL SCIENCES

1/99- Present. Adjunct Professor, Dept. of Pharmacology and Toxicology, Univ. of Kuopio, Finland
8/97- 8/98. Assistant Professor, Dept. of Pharmaceutical Chemistry, Univ. of Kuopio, Finland
12/95- 3/97. Assistant Professor of Research (Visiting Scholar) Dept. of Neurology, Univ. of Miami
10/93- 7/95. Head Chemist for MAP Medical Technologies Oy, Tikkakoski, Finland.
1/90- 1/95. Project Researcher Depts. of Pharmacol. & Toxicol. and Pharm. Chemistry, Univ. of Kuopio.
10/85- 9/88. Staff Research Associate, Univ. of California at San Francisco (UCSF) School of Pharmacy
8/85- 8/88. Volunteer Laboratory Medical Technologist and phlebotomist for the Haight Ashbury Free Medical Clinic (HAFMC) in San Francisco, California. Emergency Medical Technician for Rock Medicine (the HAFMC first aid team for rock concerts and festivals in the San Francisco Bay area).

Teaching Experience

9/91-5/93. Teaching Assistant in pharmaceutical chemistry; University of Kuopio, Finland.
9/89-5/95. Instructor of physical education (Chen's Tai Chi Chuan), University of Jyvaskyla, Finland.
9/89-5/93. Instructor of adult English (evening classes) through several institutions in Central Finland.
9/89-5/92. Instructor of crafts (stained glass techniques) in Jyvaskyla, Finland
5/81- 5/84. Teaching Assistant in organic chemistry; Dept. of Chemistry, University of Mississippi.
Spring 83. Assistant Instructor of science; Rust College, Holly Springs, Mississippi.

CHRONOLOGICAL LISTING OF PUBLICATIONS

Original Peer Reviewed Articles

Callaway JC, McKenna DJ, Grob CS, Brito GS, Raymon LP, Poland RE, Andrade EN, Andrade EO (1999). Pharmacology of hoasca alkaloids in healthy humans. Journal of Ethnopharmacology 65(3):243-256.

Callaway JC and Grob CS (1998). Ayahuasca preparations and serotonin reuptake inhibitors: a potential combination for adverse interaction. Journal of Psychoactive Drugs 30(4):367-369.

Pähkala R, Rägo L, Callaway JC, Airaksinen MM (1997). Binding of pinoline on the 5-hydroxytryptamine transporter: competitive interaction with [3H]citalopram. Pharmacology and Toxicology 80:122-126.

Callaway JC, Weeks RA, Raymon LP, Walls HC, Hearn WL (1997). A positive Urinalysis from hemp (Cannabis) seed oil. Journal of Analytical Toxicilogy 21(4):319-320.

Callaway JC, Tennilä T, Pate DW (1997). Stearidonic acid, another omega fatty acid in hemp seed. Journal of the International Hemp Association 3(2)61-63.

Callaway JC, Raymon LP, Hearn WL, McKenna DJ, Grob CS, Brito GS, Mash DC (1996). Quantitation of N,N-dimethyltryptamine and harmala alkaloids in human plasma after oral dosing with Ayahuasca. Journal of Analytical Toxicology 20:492-497.

Callaway JC, Airaksinen MM, Salmela KS and Salaspuro M (1996). Formation of tetrahydroharman (1-methyl-1,2,3,4-tetrahydro-beta-carboline) by Helicobacter pylori in the presence of ethanol and tryptamine. Life Sciences 58(21):1817-1821.

Grob CS, McKenna DJ, Callaway JC, Brito GS, Neves ES, Oberlander G, Saide OL, Labigalini E, Tacla C, Miranda CT, Strassman RJ, Boone KB (1996). Human psychopharmacology of Hoasca, a plant hallucinogen used in ritual context in Brasil. Journal of Nervous and Mental Disease 184(2):86-94.

Leppälä J, Kallio M, Nikkinen T, Liewendal K, Jääskeläinen J, Savolainen S, Gylling H, Hiltunen J, Callaway J, Kahl S & Färkkilä M (1995). Accumulation of 99mTc-low-density protein in human malignant glioma. British Journal of Cancer 71:383-387.

Callaway JC, Airaksinen MM, McKenna DJ, Brito GS & Grob CS (1994). Platelet serotonin uptake sites increased in drinkers of ayahuasca. Psychopharmacology 116(3):358-387.

Callaway JC, Gynther J, Poso A, Vepsäläinen J & Airaksinen MM (1994) The Pictet-Spengler Reaction and Biogenic Tryptamines: Formation of Tetrahydro-b-carbolines at Physiological pH. Journal of Heterocyclic Chemistry 31:431-435.

Airaksinen MM, Callaway JC, Nykvist P, Ragö L, Kari E & Gynther J. (1993). Binding Sites of [3H]Pinoline. In Melatonin and the Pineal Gland. Elsevier Science Publishers B.V., Excerpta Medica-Amsterdam, pp. 83-86.

Callaway JC, Morimoto H, Gynther J, Airaksinen MM & Williams PG (1992). Synthesis of [3H]pinoline, an endogenous tetrahydro-b-carboline. Journal of Labelled Compounds and Radiopharmaceuticals 31(5):355-364.

Airaksinen MM, Gynther J, Poso A, Callaway JC and Navajas C (1991). Structural requirements for high binding affinity to the 5-HT transporter for b-carbolines. British Journal of Pharmacology 104:370P.

Kahl SB; Callaway JC (1989).New tumor localizers: advances in the use of low density lipoproteins (LDL). Strahlentherapie und Onkologie 165:137-9.

Tozer TN; Callaway J; Hellgath M; Mahachai V; Effeney DJ and Pond SM (1989). Concurrent determination of hepatic bioavailability of salicylamide by three techniques in the dog. Journal of Pharmaceutical Sciences 78:462-464.

Callaway JC (1988). A proposed mechanism for the visions of dream sleep. Medical Hypotheses 26:119-124.

Mattern DL; Callaway JC (1987). 9(10)-Alkoxystearic acids lengthen the circadian period of a fatty acid auxotroph of Neurospora crassa. In Advances in Chronobiology, Part A:35-45.

Callaway JC; Mattern DL (1984). Ether-knobbed fatty acids lengthen the Neurospora circadian period. Biochemistry 23:3360.

Callaway JC; Mattern DL (1984) Conidial harvest from solid media using fiberglass screening. Neurospora Newsletter 31:32.


General Articles and Translations

Callaway JC (1999). Set, setting and dose. Eleusis (in press).

Callaway JC (1998). Formation of trans-fatty acids in heated hemp seed oil: A rebuttal. Journal of the International Hemp Association 5(2):106-108.

Callaway JC (1998). FIN-314: une ressource alimentaire (in French). Les Echos du Chanvre 11:7.

Laakkonen TT and Callaway JC (1998). Update on FIN-314. Journal of the International Hemp Association 5(1):34-35.

McKenna DJ, Callaway JC, Grob CS (1998). The scientific investigation of ayahuasca: A review of past and current research. The Heffter Review of Psychedelic Research 1:65-77.

Callaway JC, Weeks RA, Raymon LP, Walls HC, Hearn WL (1997). Analyses d'urine positives au THC avec de l'huile de graines de chanvre. Les Echos du Chanvre 8:9-9.

Callaway JC (1996). Yes, we may use the 'p' word! Intergation- Journal of Mind Moving Plants and Culture 6:67-68.

Callaway JC and Hemmilä AM (1996). Cultivation of Cannabis fiber varieties in Central Finland. Journal of the International Hemp Association 3(1):29-31.

Callaway JC and Laakkonen TT (1996). Cultivation of Cannabis oil seed varieties in Finland. Journal of the International Hemp Association 3(1):32-34.

Callway JC (1996). A report from the International Conference of Hoasca Studies. MAPS (Multidisciplinary Association for Psychedelic Studies) Bulletin 6(3):36-43.

Hemmilä AM and Callaway JC (1995). Hampun uudet mahdollisuudet (Hemp's new possibilities). Maatiainen December 4:38-44 (in Finnish).

Callaway JC (1995). Cultivation of hemp as a nutricious food. Hankasalmen Hamppu Seminaari (Proceedings from the Hankasalmi Hemp Seminar) 9.9.1995.

Callaway JC (1995). Pharmahuasca and Contemporary Ethnopharmacology. Curare 18(2):395-398.

Callaway JC (1995). DMTs in the Human Brain. In Jarbuch für. Ethnomedizin und Bewußtseinsforschung (Yearbook for Ethnomedicine and the Study of Consciousness) 4:45-54.

Callaway JC, Airaksinen MM & Gynther J (1995). Endogenous b-Carbolines and other Indole Alkaloids in Mammals. Integration-Journal of Mind Moving Plants and Culture 5:19-33.

Callaway JC (1995). Ayahuasca, Now and Then. Eleusis, SISSC Information Bulletin (Società Italiana per lo Studio degli Stati di Coscienza) 1:4-10 (parallel texts in English and Italian).

Callaway JC (1994). Some chemistry and pharmacology of ayahuasca. In Jarbuch für. Ethnomedizin und Bewußtseinsforschung (Yearbook for Ethnomedicine and the Study of Consciousness) 3:295-298.

Callaway JC (1994). May we use the 'p' word now? Intergation- Journal of Mind Moving Plants and Culture 4:55-56.

Callaway JC (1994). Another warning about harmala alkaloids and other MAO inhibitors. MAPS (Multidisciplinary Association for Psychedelic Studies) Bulletin 4(4):58.

Callaway JC (1993). Tryptamines, b-carbolines and you. MAPS Bulletin 4(2):30-32.

Callaway JC (1992). Our friends the xanthines. Myrtti 2:15-19.


Book Chapters

Callaway JC (1999). Phytochemistry and Neuropharmacology of Ayahuasca. In Ayahuasca: Consciousness and the Spirits of Nature, Ralph Metzner (Ed.), Thunder's Mouth Press (in press).

Callaway JC and McKenna DJ (1998). Neurochemistry of psychedelic drugs. In Drug Abuse Handbook, S.B. Karch (Ed.), CRC Press, Boca Raton, chapter 6.6, pp. 485-498.

Callaway JC (1997). Hemp seed as a nutritious crop at high latitudes. In Proceedings from the Commercial & Industrial Hemp Symposium, Wiseman Noble Publishers Vancouver, British Columbia, Canada (in press).

Callaway JC (1996). PCP, STP, Etc. In Alucinógenos: La Experiencia Psicodélico. L San, M Gutiérrez and M Casas (Eds.). Ediciones en Neurociencias (publisher), Barcelona. CITRAN (Centro de Investigacíon, Tratamiento y Rehabilitacíon de Adictos a los Narcóticos) Monografías De Toxicomanías #7 (in Spanish), pp. 95-104.

Callaway JC (1996). Ayahuasca Pharmacology (Farmacología de la ayahuasca). In Alucinógenos: La Experiencia Psicodélico. L San, M Gutiérrez and M Casas (Eds). Ediciones en Neurociencias (publisher), Barcelona. CITRAN (Centro de Investigacíon, Tratamiento y Rehabilitacíon de Adictos a los Narcóticos) Monografías De Toxicomanías #7 (in Spanish), pp. 85-94.

Callaway JC (1994). b-Carbolinas endógenas y otras alcaloides indólicos en los mamíferos. In Plantas, Chamanismo y Estados de Consciencia; J.M. Fericgla (Ed.), Los Libros De La Liebre De Marzo, Barcelona (in Spanish), pp. 197-219.

V-P Ranta, Callaway JC and Naaranlahti T (1994). Electrochemical detection of alkaloids in HPLC. In Alkaloids; Modern Methods of Plant Analysis; HF Linskens and JF Jackson (Eds.), Springer-Verlag Gmbh& Co., Berlin, volume 15 pp. 91-114


Monographs:

U Kolehmainen, JC Callaway and A Hemmilä, editors (1995). Hamppu kulttuurikasvina: Hankasalmen hamppuseminaari, ISBN 951-96529-2-2 (Proceedings from the Hankasalmi Hemp Seminar, mostly in Finnish).

Callaway JC (1994). Pinoline and Other Tryptamine Derivatives: Formations and Functions; 122 pp., a doctoral dissertation for the Department of Pharmaceutical Chemistry at the University of Kuopio, Finland. Kuopio University Printing Office, ISBN 951-780-553-5.

Callaway JC (1984) Effects of novel 'knobbed' fatty acids on a circadian rhythm of Neurospora crassa. Master of Science Thesis, University of Mississippi, May of 1984.


Conference Organizing:

Co-chair with C.S. Grob, M.D. of Phytochemical studies of the plants, Mariri and Chacrona. The International Conference of Hoasca Studies; 2-4 November 1995, Rio de Janeiro, Brazil.

Co-organizer with Anita Hemmilä and Ulla Kolehmainen of the Hamppu kulttuurikasvina: Hankasalmen hamppuseminaari (Hemp as a Cultural Plant: The Hankasalmi Hemp Seminar) Niemisjärven maamiesseurantalossa; 9 September 1995, Niemisjärvi, Finland.

Co-organizer with J. Fericgla, Ph.D. of the II International Congress for the Studies of Modified States of Consciousness: Ethnocognition, Shamanism, Plants and Cultural Context; 3-7 October 1994, Lleida, Spain.


Conference Proceedings

Callaway JC (1998). Hemp seed as a nutritious food resource. 'Bast Fiberous Plants Today and Tomorrow', Breeding, Molecular Biology and Biotechnology, St. Petersburgh, Russia, September 28-30.

Callaway JC (1998). Hemp seed as a cash crop at high latitude. The 1st Conference on Flax and Hemp Processing NORDFLAX 1, Tampere, Finland, August 10-12 (lecture and proceeding).

Callaway JC (1998). Pleasures and pitfalls of hemp seed as food. The Commercial & Industrial Hemp Symposium, Vancouver Trade & Convention Centre, Canada, February 18 & 19 (transcribed lecture).

Callaway JC (1998). Hamppuviljely- mitä varten? (Why grow hemp?). Hamppu tulevaisuuden kasvi: Kaksikielinen seminar kuiti- ja öljyhampusta. Norrvalla Center, Vöyri, Finland, 16 January (lecture).

Callaway JC (1997). Hemp seed as a nutricious cash crop at high latitude. The Commercial & Industrial Hemp Symposium, Vancouver Trade & Convention Centre, Canada, February 18 & 19 (transcribed lecture).

Callaway JC (1996). Pharmacognosy, Neuropharmacology and Pharmacokinetics of Ayahuasca. Invited speaker for Entheobotany: Shamanic Plant Science, A Multi-Disciplinary Conference on Plants, Shamanism and Ecstatic States. Palace of Fine Arts, San Francisco, California, October 18-20 (lecture).

Callaway JC, Airaksinen MM, Salmela KS, Salaspuro M (1996). Formation of tetrahydroharman (1-methyl-1,2,3,4-tetrahydro-b-carboline) by Helicobacter pylori in the presence of ethanol and tryptamine. XXIV Nordic Meeting on Biological Alcohol Research (BAR) in Imatra, Finland, May 24-26 (lecture).

Callaway JC (1995). Phytochemical studies of the plants, Mariri and Chacrona. The International Conference of Hoasca Studies, Rio de Janeiro, Brazil, November 2-4 (lecture).

Callaway JC (1995). Serotonin uptake profiles in users of Hoasca and controls. The International Conference of Hoasca Studies, Rio de Janeiro, Brazil, November 2-4 (lecture).

Callaway JC (1995). DMT, 5-HT and Dreams. The International Conference of Hoasca Studies, Rio de Janeiro, Brazil, November 2-4 (lecture).

Callaway JC (1995). Pharmahuasca and Contemporary Ethnopharmacology. 12th International Convention of the Society of Ethnomedicine, Ludwigs-Maximilians University, Munich, Germany. 'Sucht und Veränderte Bewusstseinszustände im Kulturvergleich'(Addiction and Altered States of Consciousness in Transcultural Comparison), Oct. 5-7 (lecture).

Callaway JC (1995). PCP, STP, Etc. CITRAN (Centro de Investigacíon, Tratamiento y Rehabilitacíon de Adictos a los Narcóticos) 7th Annual Meeting: The psychedelic experience, from LSD to XTC (La éxperiencia Psicodélica: Del LSD al Éxtasis) Sitges, Spain May 5&6 (lecture).

Callaway JC (1995). Ayahuasca Pharmacology. CITRAN (Centro de Investigacíon, Tratamiento y Rehabilitacíon de Adictos a los Narcóticos) 7th Annual Meeting: The psychedelic experience, from LSD to XTC (La éxperiencia Psicodélica: Del LSD al Éxtasis) Sitges, Spain May 5&6 (lecture).

Callaway JC (1994). Some chemistry and pharmacology of ayahuasca. II International Congres for the Study of the Modified States of Consciousness: Ethnocognition, Shamanism, Plants and Cultural Context. Lleida, Spain October 3-7 (lecture).

Callaway JC (1994). Chemistry and pharmacology of ayahuasca. The 12th Internordic Symposium on Pharmaceutical Chemistry. University of Kuopio, Finland August 25-28 (lecture).

Callaway JC (1992). Endogenous b-Carbolines and other Indole Alkaloids in Mammals. I International Congress: Plants, Shamanism and States of Consciousness; The Plant Hallucinogens in the Cultural Context. Museo Regional Potosino, San Luis Potosi, Mexico November 16-20 (lecture).

Callaway JC, Rägo L, Airaksinen MM, Gynther J, Nykvist P and Vepsäläinen J (1992). Endogenous b-carbolines, formation and activity. Neuroscience Finland. Turku, Finland October 8-9 (poster).

Airaksinen MM, Callaway JC, Nykvist P, Rägo L, Kari E and Gynther J. Binding sites for [3H]pinoline. (1992) Satellite Symposium of the IXth International Congress of Endocrinology; Melatonin and the Pineal Gland from Basic Science to Clinical Application. Paris, France September 6-9 (poster).

Callaway JC (1992). Transcendental napping (TN), the psychedelic siesta. 12th International Transpersonal Conference. Prague, Czechoslovakia June 20-25 (lecture).

Callaway JC (1992). Tryptamines, b-carbolines and you. The 12th International Transpersonal Asociation Conference. Prague, Czechoslovakia June 20-25 (lecture).

Callaway JC, Vepsäläinen J, Gynther JP, Airaksinen MM (1992). Observed formation of b-carbolines under simulated physiological conditions using 1H-NMR. XV National NMR Symposium. Kuopio, Finland June 4-5 (poster).

Gynther J, Poso A, Navajas C, Callaway JC, Konschin H, Rouvinen J (1991). Computer aided modeling of the citalopram binding site using theoretical characterization of b-carbolines. Kemia-kemi. Helsinki, Finland (poster).

Callaway JC, Gynther J, Airaksinen MM, Navajas C, Poso A (1991). 6-Methoxy-tetrahydro-b-carboline and its place in the serotonergic system. 'New perspectives in serotonin pharmacology'. IBC meeting. Philadelphia, PA, USA October 28-29 (poster).

Gynther J, Callaway JC, Navajas C, Poso A, Airaksinen MM (1991). Synthesis, binding affinities to the 5-HT transporter and QSAR studies of some b-carbolines. 5th Nordic Neuroscience Meeting. Kuopio, Finland June 12-15 (poster).

Callaway JC (1989). Do endogenous psychedelics catalyze the visions of dream sleep? 6th Annaual International Conference of the Association for the Study of Dreams. University of London, England July 25-29 (lecture).

Mattern DL, Callaway JC (1985) 9-and10-Alkoxystearic acids lengthen the circadian period of a fatty acid auxotroph of Neurospora crassa. (Chronobiologia 12:252P) XVII International Society for Chronobiology Conference. Little Rock, AR, USA November 17-19 (poster).

Callaway JC; Mattern DL (1984) 'Ether knobbed fatty acids lengthen the Neurospora circadian period'. 188th ACS National Meeting Abstracts . Philadelphia, PA, USA (poster).

Callaway JC; Mattern D.L. (1984) Effects of 9- and 10-Alkoxystearic acids on the Neurospora circadian period. Neurospora Newsletter 31:16. 12th Neurospora Information Conference at Asilomar, CA USA March (poster).


Invited Presentations

Graduation ceremonies for the University of Kuopio, Finland, June 6, 1996. Presented the 'Ceremony of the Robe' speech to the graduating class of new doctors.

'Neutron capture therapy in Finland today'. Grand Rounds, Department of Radiation Oncology, Kuopio University Hospital, Kuopio, Finland, May 23.

'Neuropharmacology of Ayahuasca'. National Center for Toxicological Research (NCTR) Jefferson, Arkansas, April 9, 1996. Invited by Sayed Ali, Ph.D., Director of Toxicological Research.

'Endogenous tryptamine derivatives and their putative relation to substance misuse'. Magnushus Klinika; Karolinka Institute, Stockholm; April 27. Invited by Prof. Em. Bo Holmstedt and Prof. Rydberg, M.D.

Guest Speaker at the 7th Annual Meeting of CITRAN (Centro de Investigacíon Tratamiento y Rehabilitacíon de Adictos a los Narcóticos): The Psychedelic Experience, from LSD to XTC (La éxperiencia Psicodélica: Del LSD al Éxtasis). May 5&6, 1995, Sitges, Spain.

'Ayahuasca in Modern Society'. University of Oulu, Dept. of Pharmacology; September 20, 1995. Invited by Prof. Pentti Arvela.


Other:

Sole proprietor of Finola (www.finola.com); producer of fine hempseed oil since 1998

Co-founder of the Hankasalmi Hemp Project in 1995 with Anita Hemmilä and Ulla Kolehmainen (Cultural Secretary of Hankasalmi County)

Over 50 articles in Finnish newspapers and magazines, since 1995, that specifically mention the Hankasalmi Hemp Project

Acknowledged by the leaders of Hankasalmi County, Finland, on the independance day celebration (6.12.95) for 'reintroducing a culturally useful crop', i.e. hemp.

Patent pending for 'Cannabis Products' in Finland, Patenttihakumus nro: 971876

Television interview, Channel 1: Rannikkokanava (Kustkanalen) nro. 9988, 4 October 1997, 17:30-18:00, a Finnish-Swedish series. This issue focused on hemp in Finland.

Interviewed by Tuula Martikainen in Kotilääkari 4, April 1998. 'Huumeet', pp. 31-33, 90-91.

Featured in Suomen Luonto (Finland's monthly nature magazine), February 1999, pp. 45 'Hampunsiemenöly on tervestuote (Hempseed oil is a healthy food product)'.

Interviewed by Raija Uljas for Voi Hyvin #3, pp. 27-29 (Finland's polular health food magazine).

Interviewed by Riitta Eskola for Galenos (in press, Finland's popular pharmacy magazine).